Background: Acne is a common disorder with a more prevalence among adolescents and often it 
causes atrophic scars. Several treatment options are available for acne and atrophic acne scars 
treatment. The objective of the study was to compare the efficiency of fractional CO2 laser and 
chemical peeling versus chemical peeling alone in treatment of acne and acne scars. 
Methods: Thirty-two patients with acne and acne scars were enrolled in the study. procedure was 
done to all patients and repeated at every two weeks intervals for atotal of 4 sessions. Patients were 
followed up 4 weeks after the last session. The response to treatment was assessed by objective and
subjective methods. Results: All patients completed the study and follow up period. There was 
statistically significant improvement in the scar depth in the left sides of faces of both acne scars 
subgroups. The first acne subgroup showed statistically significant improvement in the left sides, 
while the improvement in the left sides of the second subgroup was statistically in-significant. 
Conclusion: Both fractional CO2 laser and SA high concentration gave equally effective results in 
treatment of acne vulgaris .. Yet, fractional CO2 laser is superior to mandelic acid chemical peeling in 
treatment of post acne scars even in high concentration.