Introduction: Lifestyle modification strategies (diet and exercise) currently form the main 
treatments for obesity. However, results are generally disappointing and the majority of 
people who attempt lifestyle modification regain any lost weight within 5 years. Aim of the 
Work: The aim of this study was To assess the effects of bariatric procedures (sleeve 
gastrectomy, mini-gastric bypass, sleeve gastrectomy with loop bipartition) on local GIT 
hormones, (secretin hormone, ghrelin hormone, peptide YY, glucagon-like peptide 1).
Patients and Methods: Prospective randomized study which was carried out in the 
department of General Surgery, Minia University hospital during the period from February 
2018 to February 2019. Results: 56 Cases, 48 females and 8 males, were collected with age 
ranging from 20 to 50 years old and body weight ranging from 100 to 200 Kg, and subjected 
to laparoscopic sleeve gastrectomy, mini gastric bypass and sleeve gastrectomy with loop 
bipartition. Conclusion: The effect of bariatric surgery upon glucose tolerance is likely to be 
related to increased production of the incretin hormone, GlP-1, which has a profound 
insulinotropic action, coupled to the improved insulin sensitivity resulting from weight loss.