Introduction: Urticaria is defined as the sudden development of transient hives (wheals) and 
angioedema or both. Urticaria can be classified according to the duration into acute urticaria (AU) and 
chronic urticaria (CU). Aim of the work: The aim of this work is to study the amount of total IgE in 
patients with chronic urticaria in correlation to patients' characteristics and clinical severity. Patients 
and Methods: This study was conducted on 100 patients with CSU diagnosed and following in 
dermatology clinic at Minia University, the age of patients ranged from 16 to 68 years old. Results: 
Total IgE results ranged from 5 to 350 IU/ml with mean ± SD of 87.8±72.7. Conclusion: elevated
serum total IgE levels are not correlated with the severity.