Beta
221080

Leptin Receptor Expression in Obesity-Associated Acanthosis Nigricans

Article

Last updated: 05 Jan 2025

Subjects

-

Tags

Healthcare research

Abstract

Background: Obesity-associated acanthosis nigricans is the most common type of acanthosis 
nigricans. Aim of wok: To detect leptin receptor expression in the skin lesion affected by obesityassociated acanthosis nigricans. Patients and methods: Twenty patients suffering from obesityassociated acanthosis nigricans were included in this prospective study. Complete history taking, 
thorough general examination and calculation of body mass index were done for all patients. Leptin 
receptor expression was investigated in skin lesion and perilesional skin by immunohistochemistry.
Results: The mean age of the patients was 19.5 ±7.561 years and the mean duration of the disease 
was 8.6 ± 6.44 years. 14 patients were females and 6 patients were males. The mean BMI of the 
examined patients was (31.5 ± 4.4). The expression of leptin receptors was significantly higher in 
skin lesions than perilesional skin of the patients. 
Conclusion: leptin receptor expression was significantly higher in skin lesions affected by obesityassociated AN. 

DOI

10.21608/mjmr.2022.221080

Keywords

Obesity, Acanthosis nigricans, leptin. 

Authors

First Name

Essam

Last Name

Mohammed

MiddleName

E.

Affiliation

Department of Dermatology , Andrology , STDS Al-Azhar university (Assiut), Egypt.

Email

-

City

-

Orcid

-

First Name

Refaat

Last Name

Mohammed

MiddleName

R.

Affiliation

Department of Dermatology , Andrology , STDS Al-Azhar university (Assiut), Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Elhakeem

MiddleName

A.

Affiliation

Department of Pathology Al-Azhar university (Assiut), Egypt.

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Riad

MiddleName

A.

Affiliation

Department of Dermatology ,Andrology And STDS At Dairout Hospital, Assiut, Egypt.

Email

-

City

-

Orcid

-

Volume

31

Article Issue

2

Related Issue

31309

Issue Date

2020-04-01

Receive Date

2022-02-22

Publish Date

2020-04-01

Page Start

308

Page End

312

Online ISSN

2682-4558

Link

https://mjmr.journals.ekb.eg/article_221080.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=221080

Order

221,080

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Leptin Receptor Expression in Obesity-Associated Acanthosis Nigricans

Details

Type

Article

Created At

23 Jan 2023