Introduction: Asthma is a chronic inflammatory disorder characterized by airway inflammation 
caused by many cells and cellular elements. Aim of the work: To find association between IL-4, 
IL-6 and IL-18 polymorphism and asthma in Egyptian patients. To find the effect of IL-4, IL-6 and 
IL-18 polymorphism on severity of asthma. Subjects and method: The asthmatic patients 
participating in this study were from Asthma and Allergy Clinic, Minia chest hospital. Seventy five of 
asthmatic patients were enrolled in this study. Results: This study was carried on 75 asthmatic 
patients from Minia chest hospital and 75 healthy controls in the period between May 2017 & January 
2018. Future studies should include more patients for more reliable assessment. Considering that 
bronchial asthma is a complex disease, the hetero-genecity of disease may cause research results to be 
in consistent. And the statistical power of a small sample associated analysis, there for, there is a need 
for larger studies to suggest any role of this cytokine gene polymorphism in bronchial asthma and 
cytokine role in asthma severity.