Sitagliptin one of the anti-diabetic drugs. We aimed to evaluate the gastroprotective effect of 
sitagliptin in indomethacin-induced peptic ulcer in rats. Adult male albino rats were divided to four
groups; control, sitagliptin (SIT), indomethacin (IND) and IND+SIT group. In each group, 
ulcer index, gastric mucosal malondialdehyde (MDA), total nitrites (NOx) and Tumor necrosis factoralpha (TNF-α) were determined. In IND+SIT group, ulcer index, MDA and TNF-α were reduced, as 
compared to IND group. At the same time, NOx was increased in IND+SIT group, as compared to 
IND group. In conclusion, sitagliptin showed gastroprotective effect in indomethacin induced peptic 
ulcer in rats mostly through anti-oxidant and anti-inflammatory actions.