Objectives: To evaluate and compare the effectiveness of atropine alone and the combined therapy of 
atropine and glycopyrrolate in treatment of patients with acute organophosphate poisoning (OP).
Patients and methods: Forty patients with history of OP poisoning were included in the study within 
the period from 1st of March 2017 to 28th of February 2018. The study is a prospective randomized 
controlled trial that was carried out on patients admitted to Poison Control Center of Minia University 
Hospital. These patients were divided in to two groups of 20 patients each. Group I was treated with 
atropine alone while group II was treated with atropine in combination with glycopyrrolate. Results: 
The majority of the patients were females (55%). The outcomes of these two groups were analyzed 
and compared including percentage of mortality, percentage of recovery, duration of hospital stay, 
need for mechanical ventilation, incidence of intermediate syndrome and percentage of adverse 
reactions.The percentage of recovery and percentage of mortality were the same between the 2 groups 
with p=1. However, there was reduction in hospitalization days and incidence of adverse drug 
reactions of the used drugs in (group II) when compared to ( group I) . Conclusion: The study 
suggests that treatment with combined therapy of atropine and glycopyrrolate was more effective than 
therapy with atropine alone regarding the reduction in the duration of hospital stay and incidence of 
adverse reactions of the used drugs.