Introduction: Neonatal hypoglycemia is the most common metabolic issue in the newborn. Aim of 
the work: This study was conducted to evaluate causes and prognosis of neonatal hypoglycemia in 
NICU in Minia university Maternity & Children hospital. Study design: The study was conducted 
between May and December 2019. First blood glucose concentrations of all infants admitted to the 
nursery were measured using a “point of care" analyzer. We recorded risk factors for hypoglycemia
such as birth weight, gestational age, and maternal diabetes and analyze their association with 
hypoglycemia. Results: Among 398 neonates, 42(10.55%) were hypoglycemic confirmed by serum 
sample. A highly significant association was found between neonatal hypoglycemia with prematurity
and infant of diabetic mother (IDM). The severity of hypoglycemia was significantly associated with 
gestational age and birth weight. Conclusions: Newborns of diabetic mother, premature and abnormal 
birth weight are at risk of hypoglycemia.