Background: sustained virological response (SVR) can be achived in high percentage of HCV 
patients with the availability of direct acting antiviral agents DAAs. We hypothesize that treatment of 
HCV with novel direct-acting antiviral may affect lipid profil in diabetic pateints who achieve 
sustained virological response after DAAs. In our study 50 Chronic HCV patients candidate to
Internal Medicine Department and Hepatology unite of One Day Surgery Hospital for treatment 
with DAAs. Measurement of total cholesterol, HDL, LDL and triglyceride level befor and after 
DAAs therapy is done. Statistical analysis was done for these data. Results: After SVR; There is 
highly statistical significant difference as regard each of cholesterol, triglycerides, HDL and LDL, 
with lower level observed after treatment (p < 0.001). Conclusions: This study shows that 
eradication of HCV by DAAs will result in a parallel decrease in lipid parameters and that may 
improve clinical outcomes in patients with stablished T2DM.