Introduction: Larynx can be involved with malignant or a spectrum of benign lesions. Benign lesions
of the larynx involve mainly chronic laryngitis, vocal cord polyp, vocal cord nodule, Reinke's edema 
and various different benign lesions. Smoking and voice abuse seem to be the most common cause 
and risk factor of laryngeal disorders. Helicobacter pylori (HP) were detected in some cases of 
chronic laryngitis. However, it has been confirmed by histology, tissue cultures or polymerase chain 
reaction in benign laryngeal lesions. Patient and methods: 40 patients of both sex, aged 6-75 years 
old, scheduled to undergo surgical excision of benign laryngeal lesions and histopathological 
examination to diagnose HP were enrolled in this prospective study. Follow up of laryngopharyngeal 
reflux (LPR), HP stool antigen test and histopathological evaluation of the biopsies to diagnose HP in 
the lesions. Results: When we compared between positive cases which was 8 by Giemsa stain and 
negative cases (32 cases), there was no statistically significant difference according to age, sex and 
LPR. But there was statistically significant difference regarding the different types of laryngeal 
lesions with the majority of positive cases found in patients with vocal fold polyp. There was also 
statistically significant difference as regard stool antigen test which showed significant agreement. 
Conclusion: HP may be considered as a reliable cause and risk factor for benign laryngeal lesions 
especially VF polyp. Also stool antigen test could be used as a reliable test for diagnosis of HP such 
as histopathological examination.