The goal of this study to detect prevalence of different causes of persistent cervical lymphadenopathy 
in Beni-Suef localities. This study had been conducted at Otorhinolaryngology department and 
radiology department, Beni-Suef University Hospital on 100 patients suffering from cervical 
lymphadenopathy not responding to medical treatment for 1month or progressively increasing size of 
lymph node within 2 weeks in spite of medical treatment. The patients (of 1- 78 years old) have done 
ultrasound guided tru-cut needle biopsy (89% of cases) and surgical excisional biopsy (11%). The 
results were 55% malignancy, 28% reactive cause, 8% TB, 3% granuloma and 6% other causes as 
SLE and pleomorphic adenoma.