Introduction: Chronic obstructive pulmonary disease (COPD) is a critically important international 
health problem. Aim of the study: The aim of this study was to: Assess the effect of different 
COPD phenotypes on disease outcomes as regard disease severity, inflammatory burden, comorbidity 
and exacerbation. Patients and Methods: Design of work The clinical study was a prospective study 
included 100 patients with stable COPD who were presented as out-patients to chest clinic at 
Cardiothoracic Minia University hospital during the period between October 2018 to December 2019.
Results: Distribution of different COPD phenotypes cases:- patients with chronic bronchitis were 
more than emphysema in both exacerbator and non exacerbator phenotypes.