Background: The study explores unilateral versus bilateral laparoscopic ovarian drilling in patients 
with clomiphene citrate resistant polycystic ovarian syndrome in terms of improving the reproductive 
hormonal profiles, ovarian reserve and ovulation outcome in El-Minia Governate. Methods:The 
effectiveness of unilateral (N: 55 women) versus bilateral (N: 55 women) LOD were done in terms of 
improving infertility outcomes in clomiphene resistant PCOD patients. Results: There is no 
significant difference in both studied groups regarding serum FSH level before and six months after 
LOD in both groups (p > 0.05), however there is a significant difference in both studied groups 
regarding serum LH level before and six months after LOD (p < 0.001). However, no significant 
difference in serum LH levels either before or after LOD when compared both groups (p > 0.05). 
There is a significant difference in both studied groups regarding the serum AMH level before and six 
months after LOD in both groups (p < 0.001) , also there is a significant differences when compared 
the two groups after six months from LOD (p < 0.01).Conclusions: Unilateral laparoscopic ovarian 
drilling had similar efficacy as bilateral laparoscopic ovarian drilling in terms of restoration of normal 
menstrual cycles, ovulation and pregnancy rates with improving both ovarian reserve and AFC.