Chronic kidney disease (CKD) is characterized by an irreversible deterioration of renal 
function that gradually progresses to end-stage renal disease (ESRD), In the past 2 decades, the 
incidence of the chronic kidney disease in children has steadily increased, with poor and ethnic 
minority children disproportionately affected (USRDS, 2010). The number of dialysis patients 
increases by 7% annually (Choi et al., 2009). About 25% to 75% of chronic renal failure (CRF) 
patients who receive hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) for long 
periods experience gastrointestinal troubles (Min et al., 2013). Aim of the work: The aim of the 
study to determine Vitamin B12 levels in Helicobacter pylori infected chronic kidney disease 
paediatric patients. Subjects and Methods: Subjects: *Study design and population: This 
prospective study was conducted at Minia University Hospital, Faculty of Medicine, Minia University 
Pediatric Hemodialysis Unit and Minia General Hospital ,during the period from April 2016 to May 
2017. Results: This prospective study was conducted at Minia University Hospital, Faculty of 
Medicine, Minia University Pediatric Hemodialysis Unit, Minia General Hospital, during the period 
from April 2016 to May 2017. Twenty five children were included in this study with chronic kidney 
disease under dialysis in the age groups between 6-16 years old, 60% males and 40 % females.