Aim: To asses clinically the effect of using platelet-rich fibrin (PRF) in revascularization of non –
vital mature teeth. Materials and methods: A total of twenty necrotic mature permanent anterior 
teeth were enrolled for pulp regeneration using two different revascularization techniques They were 
randomly divided into 2 groups (n=10): group A; was treated by blood clot (BC) revascularization 
technique (conventional) and Group B; Revascularization was done using platelet-rich fibrin (PRF). 
Clinical assessments were performed after 6 and 12 months. Results: After 12 months of follow up of 
regenerative endodontic procedure (REP), all cases in both groups free of pain, facial swelling and 
tenderness on palpation. Conclusions: Both PRF and BC revascularization techniques were 
successful clinically regarding the resolution of signs and symptoms associated with the mature 
necrotic anterior teeth.