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217924

Renal Graft Vesicoureteral Reflux Survival and Oucome in Pediatric Recipients; Single Centre Experience

Article

Last updated: 28 Dec 2024

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-

Tags

Healthcare research

Abstract

Objective: The goal of this study was to evaluate pediatric post transplant vesicoureteral reflux 
(VUR) in terms of graft's Urinary Tract Infections (UTIs) episodes, graft outcome and survival in 
comparison to grafts that don't have reflux. Subjects and Methods: A total of 145 pediatric patients 
who underwent kidney transplantation at our transplantation unit between 2008 and January 2019 and 
suited our inclusion criteria were included in this retrospective cohort study and a voiding 
cystourethrography (VCUG) was done to them and categorized into main groups; group (A) refluxing 
graft group (n=66) and group (B) non refluxing graft group (n=79). Baseline donor and recipient 
demographic characteristics, post transplant serum creatinine level at different points, graft outcome, 
and UTIs were listed. Post transplantation (Tx) UTIs and graft outcome were compared between both 
groups. Glomerular Filtration Rate (GFR) was measured using Shwartz formula. Frequency- Volume 
Chart (FVC) and UroDynamic Study (UDS) were used to identify Lower urinary Tract (LUT) 
condition and helped us regarding decision making in management of graft VUR. Results: Mean ±SD 
age at time of Tx was 8.7±3.4y in group A versus 8.9±2.8y in group B, P value=0.667. Regarding sex, 
46 patients (69.7%) were male in group A, while 56(70.9%) were male in group B, p value = 0.876. 
UTI occurrence was similar between groups {40(60.6%) patients in group A versus 49 (62%) patients 
in group B, P value=0.861 but UTIs episodes (more than 3 episode per year) was 20 (30.3%) patients 
in group A versus 1(1.3%) patient, P value =0.001. Both groups were similar in terms of 5-year 
(100% versus 98.5%), and 10-year (76.2% versus 84.7%) graft survival. Conclusions: There was no 
difference between refluxing and non refluxing graft in terms of UTIs occurrence, graft function and 
survival. Frequency of UTI episodes was more in the refluxing graft like any native kidney primary 
VUR.

DOI

10.21608/mjmr.2022.217924

Keywords

Renal transplantation, graft veisicoureteral reflux, graft VUR outcome, graft VUR treatment

Authors

First Name

Hosny

Last Name

Abd El-Ghany

MiddleName

S.

Affiliation

Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt.

Email

-

City

-

Orcid

-

First Name

Enas

Last Name

Abdel Gawad

MiddleName

A.

Affiliation

Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Esmaeel

MiddleName

M.

Affiliation

Department of Neurology and Psychiatry, El-Minia Faculty of medicine, El-Minia- Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Moneer

MiddleName

M.

Affiliation

Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Fathy

MiddleName

W.

Affiliation

Department of Neurology and Psychiatry, El-Minia Faculty of medicine, El-Minia- Egypt.

Email

-

City

-

Orcid

-

First Name

Mohmamed

Last Name

Kasem

MiddleName

H.

Affiliation

Department of Urology, Minia University Hospitals, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Tarek

Last Name

Fathelbab

MiddleName

KH.

Affiliation

Department of Urology, Minia University Hospitals, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Fatina

Last Name

Fadel

MiddleName

-

Affiliation

Pediatric renal transplantation unit, Cairo children's hospital, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Hani

Last Name

Morsi

MiddleName

Abdel-Raouf

Affiliation

Department of Pediatric Urology, Cairo children's hospital, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ayman

Last Name

Hussein

MiddleName

F.

Affiliation

Department of Urology, Minia University Hospitals, Minia, Egypt

Email

-

City

-

Orcid

-

Volume

31

Article Issue

4

Related Issue

31304

Issue Date

2020-10-01

Receive Date

2022-02-08

Publish Date

2020-10-01

Page Start

178

Page End

188

Online ISSN

2682-4558

Link

https://mjmr.journals.ekb.eg/article_217924.html

Detail API

https://mjmr.journals.ekb.eg/service?article_code=217924

Order

217,924

Type

Original Article

Type Code

2,212

Publication Type

Journal

Publication Title

Minia Journal of Medical Research

Publication Link

https://mjmr.journals.ekb.eg/

MainTitle

Renal Graft Vesicoureteral Reflux Survival and Oucome in Pediatric Recipients; Single Centre Experience

Details

Type

Article

Created At

23 Jan 2023