Background: Melasma is a human melanogenesis disorder that lead to chronic, acquired 
hypermelanosis of the skin. Melasma has a significant impact on appearance, causing 
psychological and emotional distress, and reducing the quality of life of affected patients. The 
main cause of melasma has not yet been adequately studied. Objectives: This work aims to 
evaluate the role of microneedling alone or combined with PRP or vit. C in the treatment of 
melasma. Methods; the study was conducted on 20 patients with melasma. The age of 
patients ranged from18 to 42. They were divided into two groups. Results: Clinical 
improvement in most of cases which was in the form of significant improvement of 
pigmentation on both sides but more significant on Rt. side with marked overall lightening 
but more significant on Rt side. Conclusion: microneedling alone or combined with PRP or 
vit.C is a good treatment for melasma patients especially combined form.