Type I Diabetes Mellitus (TIDM) is the most common chronic metabolic autoimmune disease. Aim of 
the work: To estimate serum levels of Islet cell antibodies (ICA) in first-degree relatives of type I 
diabetic children. Subjects and Methods: Study Design: This study was a prospective case-control
hospital-based study carried upon 120 children randomly selected during the period from January 
2016 till August 2016 after approval of the ethical committee of the Faculty of Medicine, Minia 
University. Results: This table shows insignificant differences between group I and group II 
regarding age, gender, residence, weight, height, and BMI centiles where (P > 0.05). Finally, ICA 
positivity had a significant moderate negative correlation with fasting C-peptide