Aim: We aimed to assess the accuracy and predictive value of fetal cardiac screening for congenital 
heart disease (CHD) at 18-22 gestational weeks in high-risk patients. Methods: In this study of fetal 
cardiac screening, four-chamber view, three-vessel view, outflow tracts followed by Doppler were 
recorded by obstetricians at 18–22 gestational weeks. A total of 438 fetuses that were scheduled 
for delivery at our hospital were included. Results: Forty-four newborns were born with CHD 
(10.9%). The prenatal detection rate of CHD was (72.7%). Although 80% of structural abnormality 
was diagnosed antenatally, only 44.4 % of valvular abnormality was diagnosed. Conclusion: Detailed 
fetal heart scan performed by skilled obstetricians had a high detection rate for structural rather than 
valvular CHD in high-risk populations. The integration of this scan with multiple appropriate cardiac 
views into routine second trimester scan may improve the detection rate of fetal CHD and give a 
chance for parental counseling.