The increasing prevalance of methicillin resistant Staphylococcus aureus representes a significant 
threat to public health mainly due to antibiotics abuse. This study aimed to detection prevalance of 
resistant isolates of S. aureus to different antimicrobials from plastic surgery department. Methods: In 
this study, incidence of Staphylococcus aureus infection in Minia University hospital was determined 
by testing a random sample of 52 patients from wounds samples of plastic surgery department. Then, 
the disc diffusion method was used to determine the patterns of antimicrobial resistance and efficacy 
of commercial antibiotics in treatment of Staphylococcus aureus infection. Results: Prevalence of 
Staphylococcus aureus infection was 42.6% among our patients. Antibiotic resistance rates were 
alarmingly high, up to 82% in oxacillin, 77% in cefotriaxone, and 54% in amikacin and 50% in 
cefoxitin. Discussion: This Study showed unprecedented antimicrobial resistance rates of 
Staphylococcus aureus. New alternative treatment regimens should be considered and investigated to 
replace the current ineffective therapies.