Introduction: For a couple of decades particularly, both the increase in average age throughout the world and the developments in diagnostic technologies have gradually increased the importance of lumbar degenerative diseases in the practice of neurosurgery. Aim of the Work: The aim of this work is to evaluate the role of transforaminal lumbar interbody fusion with a single oblique cage and unilateral pedicular fixation in the treatment of degenerative lumbar disc disease . The results were recorded, tabulated & finally analyzed. Patients & Methods: This prospective study included thirty patients with degenerative lumbar disc diseases treated by lumbar interbody fusion using unilateral pedicular fixation. All surgeries were performed in the spine unit at Minia University Hospital, El Minia, Egypt. Patients were followed up for at least 6 months, and all of them were consented. Results: Follow up: All patients will be followed up closely; day after day for wound care until the removal of stiches after 15 days, clinical examination and radiographies will be performed at one month, three months, 6 months, 9 months and one year intervals after the operation. Conclusion: 1- Unilateral PS instrumented TLIF is a viable treatment option for treating Degenerative disc disease as it successfully achieves: a- Direct and indirect decompression and hence addressing the main pathology which is the nerve root compression. b-One stage circumferential fusion. 2-UNI-TLIF produces good results especially in terms of operative time, blood loss, implant costs, and hospital time for single or double-level diseases. 3- UNI-TLIF should be extended to include other inclusion criteria. 4-An improved study design and longer period of follow-up are still needed to confirm this effect.