Introduction: Verrucae are benign epithelial proliferations, caused by human papillomavirus (HPV) 
infection occurring on the skin and mucosa. Traditional therapeutic options for warts, such as topical 
therapy, cryotherapy, surgical excision, and electrocautery, have proven somewhat effective, but these 
approaches may offer incomplete and superficial results leading to high recurrence rates. Laser therapy 
offers an alternative solution to traditional treatment methods. Methods: The study was carried out on 
50 patients presented with common wart (verruca vulagris) 250 lesions (100 lesions treated with 1064 
nm Nd-YAG laser, 100 lesions treated with 577 nm Diode laser, and 50 lesions as control). All 
patients attended to the laser unit of the Dermatology and Andrology department at Al-Azhar 
University Hospital (Assiut) between December 2019 and July 2020. Results: Considering lasers 
efficacy, most of wart lesions were completely disappeared after 1st session of laser treatment, with no 
significant difference between Nd-YAG and Diode lasers, moreover, most of control wart lesions 34 
(68%) had no changes, while 16 (32%) were completely disappeared after treatment, with no 
significant complications detected in most of patients. Conclusion: 1064 nm Nd-YAG laser and 577 
nm Diode laser, can be used as safe and effective monotherapy for the treatment of viral warts. Factors 
as younger age, skin photo type III of patients, short duration, small size and 1st appearance of lesions, 
can be used as predective parameters for the treatment.