There are no current screening or surveillance guidelines for CRC in Egypt, and most individual screening is scarcely done. Consequently, many cases of CRC are diagnosed in a late stage. Hence, we are in a natural and urgent need to formulate Egyptian guidelines that suit our population, our physicians and compel our limited health resources. If developed and implemented, these guidelines will help detect early stages of CRC, reduce cancer-related treatment expenses, and improve the prognosis.  The awareness of both the public and the physicians about this preventable cancer needs enhancements.