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209266

Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier

Article

Last updated: 23 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

The area comprises prevention, diagnosis, and management of gastrointestinal and Hepatobiliary disorders and related molecular, genetics,
The fields related to gastroenterology and Hepatology.

Abstract

Aims: This study used an animal xenograft model of gastric cancer induction to investigate the therapeutic effects of capecitabine polyamidoamine (PAMAM) dendrimer complex against cancer and its potential side effects. Methods and Materials: Human gastric cancer tissue was obtained from patients with gastric carcinoma and transplanted into mice. Anticancer drug capecitabine was loaded into PAMAM dendrimer nano-carrier and injected into the animals. All animals received cyclosporine before the surgery. Results: Capecitabine-dendrimer complex reduced the size of the axillary implanted tumor, the levels of AST and ALP, and the drug-induced adverse effects on other body organs. Furthermore, it increased apoptotic and necrotic responses in the grafted tumor, RBC, WBC, and platelet counts compared to free capecitabine. Conclusions: In gastric cancer settings, the PAMAM dendrimer drug delivery method effectively improved therapeutic index and outcomes and reduced undesirable side-effects of the capecitabine.

DOI

https://dx.doi.org/10.52378/fkh195276

Keywords

Gastric cancer, Xenograft, Capecitabine, Cyclosporine, Poly amidoamine dendrimer (PAMAM), Mice

Authors

First Name

Sharareh

Last Name

Jafari

MiddleName

-

Affiliation

Electrophysiology Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Department of Physiology, Medical school, Tehran University of Medical Sciences, Tehran, Iran

Email

-

City

tehran

Orcid

-

First Name

Fatemeh

Last Name

Nabavizadeh

MiddleName

-

Affiliation

Department of Physiology, Medical school, Tehran University of Medical Sciences, Tehran, Iran

Email

nabavizadeh@tums.ac.ir

City

tehran

Orcid

-

First Name

Jalal

Last Name

Vahedian

MiddleName

-

Affiliation

Department of Surgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Email

-

City

tehran

Orcid

-

First Name

Mehdi

Last Name

Ardestani

MiddleName

Shafie

Affiliation

Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Email

-

City

tehran

Orcid

-

First Name

Hedayat

Last Name

Samandari

MiddleName

-

Affiliation

Electrophysiology Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Email

-

City

tehran

Orcid

-

First Name

Ali

Last Name

Mehrjerdi

MiddleName

Zare

Affiliation

Department of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Email

-

City

tehran

Orcid

-

Volume

2

Article Issue

1

Related Issue

29432

Issue Date

2019-02-01

Receive Date

2019-02-12

Publish Date

2019-03-24

Page Start

30

Page End

55

Print ISSN

2735-5489

Online ISSN

2735-5497

Article File

AJGH_Volume 2_Issue 1_Pages 30-55.pdf

PDF . 765.0kB

Link

https://ajgh.journals.ekb.eg/article_209266.html

Detail API

https://ajgh.journals.ekb.eg/service?article_code=209266

Order

3

Type

Original Clinical

Type Code

2,189

Publication Type

Journal

Publication Title

African Journal of Gastroenterology and Hepatology

Publication Link

https://ajgh.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

23 Jan 2023