Background: In clinical practice many wounds are slow to heal and difficult to manage. And so, this study was performed to evaluate the effect of Negative Pressure Wound Therapy on patient with lower limb ulcers. Methodology: thirty patients were included in this study. Their ages ranged from 50 to 70 years, divided into two groups:Group (A) received traditional medical treatment for 6 weeks. Group (B) received treatment with negative pressure wound therapy plus traditional medical treatment, 3 days/week for 6 weeks. The measurements were done before the study and after 6 weeks of treatment for both groups by using wound volume (saline injection) and wound surface area tools (Tracing method). Results: It showed reduction in the wound volume and wound surface area after treatment for group (A) and (B), with percentage of 7.79 %., 42.39 %, respectively for the wound volume and 10.51 %, 37.57 %, respectively for wound surface area. There was a highly significant difference between two groups after the treatment.  Conclusion: Negative Pressure Wound Therapy was found to facilitate the rapid of granulation tissue and shorten healing time of the lower limb ulcers.