Xenobiotics are continuously exposed to the liver, which can cause several significant liver diseases. To determine if they are suitable for treating chemically induced liver injuries in experimental animals, various plant products have been examined for their potential hepatoprotective properties. The effect of different heart of palm date powder concentrations 2.5, 5.0, and 7.5% on the biological and biochemical alterations in the livers of rats were evaluated. Twenty-five white male albino rats weighing 140±10g each were placed into 5 groups with 5 animals each. Rats infected with hepatic by injecting carbon tetra chloride (CCl4) 0.2 ml/100 g body weight of 40 ml/l CCl4 dissolved in paraffin oil. After being starved for one day, rats were slaughtered, and blood was collected and processed to separate the serum. Serum liver functions (ALT, AST, and ALP) and oxidative enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) activity, serum lipid profile (T.G., T.C., LDL-c, HDL-c, VIDL-c), and renal functions (uric acid, urea, and creatinine), were also determined. The HPLC technique was also used to identify phenolic compounds. The HPLC results showed that the heart of palm contained many bioactive compounds. The obtained results of hepatic rats indicated that heart of palm powder improve serum liver functions, kidney functions, lipid profile and oxidative enzymes in rats especially 7.5% levels. As conclusion, heart of palm powder could be used in our beverages and daily dishes, besides the fact that it has so many health benefits.