Camel milk was known for its unique value which makes it a valuable source in the field of medicine as antidiabetic, wound healing, anti-microbial, hepatoprotective and antiulcer agents. Therefore, the current study was performed to investigate the potential effect of probiotic camel milk-enriched with papaya oil or extract as antioxidant and antiulcer agents on indomethacin-induced gastric ulcers in rats. Thirty-five male albino rats (190 - 200g), were fed on a standard diet and divided into seven groups (5 rats each). Rats of the first group received distilled water and served as normal control. While the other six groups were induced gastric ulceration by a single oral dose of indomethacin (30 mg/kg BW), then these groups were classified into ulcer control,  PCM (probiotic camel milk 5 ml /kg BW), PO (papaya oil 5 ml /kg BW), PE (papaya extract 5 ml /kg BW) and their mixture (PCM plus PO), and (PCM plus PE) in 1:1 (v/v) ratio (PCM: PO/or PE). At the end of the study (5 weeks), blood and stomach samples were collected for biochemical analysis. The results revealed that administration of probiotic camel milk significantly (P< 0.05) increased gastric pH, the curative ratio of gastric ulcer length, Cyto P450, PGE2 relative to indomethacin-induced ulcer rats. The most effective treated groups were probiotic camel milk incorporated with papaya oil or followed by papaya oil which significantly (P< 0.05) decreased gastric ulcer length, the volume of gastric juice, Cox-2 compared with the ulcer group. Activities of glutathione peroxidase, superoxide dismutase in the probiotic camel milk enriched with papaya oil or extract groups were increased significantly compared to the ulcer group (P< 0.05). The current study concluded that probiotic camel milk enriched with papaya oil or extract treatment may play a protective role against indomethacin-induced gastric ulcers in rats, which may be due to the enhanced antioxidant enzymes.