The aim of the study was to evaluate the potential effect of Alhagi maurorum bread on nephrotoxicity caused by CCl4 in rats. In addition, the chemicals composition (moisture, protein, fat. fiber, ash and carbohydrates). Determined also total phenolic, flavonoids and total antioxidant content of Alhagi maurorum.  Forty-two rats were divided into six equal groups. Group 1: control group (normal). Group2:  treated with CCl4 (1ml/kg body weight (b.w)), twice a week for 4 weeks. Groups 3, 4, 5 and 6 were treated with the same dose of CCl4 administered with Alhagi maurorum bread at concentrations 2.5, 5, 7.5 and 10% of Alhagi maurorum bread respectively.  Results appeared that rats treated with CCl4 showed a significant increment in kidney function (urea and creatinine), total lipid, cholesterol, triglycerides and malondialdehyde (MDA), but a significant decline in the mean values of Glutathione peroxidase (GPx) and Total Antioxidant capacity (TAC) as compared with the control group. The treatment with Alhagi maurorum bread (7.5 and10 %) improved the functions of the kidney These protective effects were depends on concentration of Alhagi maurorum in bread. Alhagi maurorum has a protective effect against the loss of antioxidant activities as a result of the oxidative process caused by CCl4 injection due to its phytochemicals compounds (phenolic and flavonoids) and antioxidants. This protective activity of Alhagi maurorum bread suggests that regular consumption of it or food containing phenolic, flavonoids and antioxidants may protect against Nephrotoxicity and imbalanced antioxidants. Thus, the possibility that Alhagi maurorum bread reduces the risk Nephrotoxicity.