This study aims to investigate the effect of Shea seeds on the rat infected with fatty liver. This study was conducted on twenty five male albino rats weighing (150g± 10) and classified into five groups as follows: control (-ve), control (+ve), 5% Shea seeds powder, 10%shea seeds powder and Shea seeds extract rats groups. The last four groups were given by oral with amitriptyline (1m-mL-100g/ rats) for two weeks of the experiment to induce hepatic injury. The study was assigned for seven week