The plant of Moringa oleifera has been taken part in many therapeutic functions. The helpful oil from Moringa seeds has its profitable sides to the people who have this tree in their neighborhoods. To evaluate whether addition of 10, 20 and 30% M. oleifera oil has defensive potential against Potassium bromate, which was generated from nephrotoxicity in rats. Male Wistar rats were nominated and devided into five groups. Each group consists of five rats. Those rats were injected a single intra-peritoneal of potassium bromate at a dose level 125 mg /kg body weight. That lasted on either normal diet or diets enriched with Moringa oleifera oil at many levels of concentrations for 6 weeks. At the last, after (45 days), the rats were given up to get blood samples for biochemical analyses. KBrO₃ showed losing weight   in rats, caused powerful rising in the levels of plasma, liver enzymes, creatinine, and uric acid and increased the oxidative stress on rats. In contrast, plasma liver enzymes, creatinine, uric acid levels ameliorated by the addition of M. oleifera oil to diets. Morever, M. oleifera oil especially at level 20% to diets was a reason in great increase (p<0.5) in SOD, GPX and GST, while caused serious decrease (p<0.5) in MDA levels. It was recongnized that addition of M. oleifera oil at level 20% to diet supported powerful defense against KBrO₃-generated nephrotoxicity.