The increased incidence of cardiovascular diseases and hyperlipidemia was observed among the Egyptians in the last decades. The present study aims to explore the role of Purslane on some biological activities of hyperlipidemic rats. Therefore,  different concentrations ranged 200 to 400 mg/kg body weight (BW) of Purslane extract were consumed by hyperlipidemic rats and the plasma total cholesterol, triglycerides, HDL-c, LDL-c, lipid peroxide as well as total antioxidants capacity levels were investigated. Results revealed that significant differences (P<0.01) among all experimental groups regarding total cholesterol, triglycerides, HDL-c, LDL-c, lipid peroxide and total antioxidants capacity levels were observed. Concentration of 400 mg/kg BW of purslane extract recorded the most decrease in all previous plasma parameters except the HDL-c and total antioxidant capacity levels which recorded the opposite direction.