The present study was carried out to investigate the effect of globe artichoke on high fat and fructose (HF/HFr) diet on the onset of the characteristics of the the levels of growing male. Also the possible protective effects of artichoke (AK) against (HF/HFr) diet induced-metabolic disturbances. Thirty sex male albino rats were randomly assigned into 4 groups and were fed for 6 weeks the following diets group 1 basal diet,  negative control (C) group 2 basal diet containing 20 g AK/kg diet (C+AK), group 3 high fat diet (15% beef tallow + 5% corn oil) combined with fructose (13% W/V) in drinking water (HF/HFr), group 4  HF/HFr diet containing 20 g AK/kg diet (HF/HFr+AK). HF/HFr diet induced elevated levels of blood glucose, serum TG, TC, LDL-C, liver, renal function and (NO) with a decrease in (HDL-C) and total antioxidant capacity compared to control. These effects were more pronounced in HF/HFr diet fed on. Globe artichoke reinstated most of the altered measured parameters. So, HF/HFr diet developed characteristics of metabolic syndrome in growing male rats. Artichoke were protected against some metabolic disturbances of HF/HFr diet. The inclusion of artichoke consumption has a beneficial effect in control and management of diabetes and diabetes associated complications with no risk of hypoglycemic effect.