Oxidative stress plays an important role in the etiology and pathogenesis of many chronic diseases such as atherosclerosis, hypertension, diabetes mellitus and cancers. Dietary intake of antioxidants can inhibit or delay the oxidation of susceptible cellular substrates so prevent oxidative stress. The present study was designed to investigate potential protective and ameliorate effects of sesame oil and jojoba oil against potassium bromate (KBrO₃)-induced oxidative stress using experimental rats. Thirty five of rats were randomly divided into five groups, seven rats each. Group 1 was fed on the basal diet and kept as a negative control group (normal rats). The other 4 groups were injected by a single intraperitoneal dose of KBrO₃ at dose of 125 mg/ kg body weight for induction of oxidative stress. Group 2 was left as a positive control group and groups 3, 4 and 5 were fed on supplemented diet with 5% sesame oil, jojoba oil and mixture of them, respectively. The obtained results revealed that the injected intoxicated groups with sesame oil (SO) or jojoba oil (JO) or mixture of them had significant reduced in serum levels of total cholesterol, triglycerides, LDL-c, total bilirubin, blood urea nitrogen, uric acid, creatinine, malondialdehyde (MDA), activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes and significant increased in feed intake, body weight gain, serum levels of HDL-c, total antioxidant capacity, reduced glutathione (GSH), activity of glutathione peroxidase (GPx) superoxide dismutase (SOD) and catalase (CAT) enzymes. Moreover, there is a significant decrease in MDA and increase in GSH content and activity of antioxidant enzymes (GPx, SOD and CAT) in liver tissues as well as partially improvements in liver structures of liver and kidneys compared to those of positive intoxicated control group. The best improvements of all the biochemical parameters and histological structures of liver and kidneys which were tended toward normal results were observed in treated KBrO3-intoxicated rats with mixture of SO with JO. In conclusion, the present findings suggested that regular intake of SO or JO may be useful in improving liver and kidney functions and may protect against KBrO₃ induced oxidative stress in rats by exhibiting stronger antioxidant activity. The mixture of SO with JO provide the preferable effects.