The present work was carried out to study the therapeutic effect of cod liver oil, flaxseed oil and zinc for enhancing fertility of rats with injured tests,  serum hormonal levels, lipid profile, blood antioxidants parameters and fatty acids in liver of rats injured with cyclophosphamide were determined. In the experiment, thirty five rats were divided randomly into seven groups (n=5).  The first group was the negative control fed on basal diet, the other groups were injected with single dose of cyclophosphamide (100 mg\ kg BW) to induce testicular injury, the second group was positive control. Other groups 3,4,5 and 6 treated with cod liver oil, flaxseed oil, mixed oils, zinc (0.5 mg/kg ) and mixed oils with zinc. The results revealed that cod liver oil, flaxseed oil, mixed oils, zinc and mixed oils with zinc increased significantly sexual hormones, specially testosterone (T), follicle stimulating hormone level (FSH) and luteinizing hormone(LH). On the other hand, elevated antioxidant enzymes response by increasing significantly total antioxidant and superoxide dismutase (SOD). The results showed that cod liver oil, flaxseed oil, mixed oils, zinc and mixed oils with zinc improved liver function when compared with positive control. The results found that polly unsaturated fatty acids in rats liver treated with cod liver oil, flaxseed oil and zinc had high content of docosahexaenoic and eicosapentaenoic acids which leads to fertility enhancement.