Background: Yakson's is a Korean therapeutic touch given to neonates and infants in which one hand 
caresses their tummy while the other rests on their back to reduce pain and quiet them down. It could 
significantly decrease the level of stress hormones and increase sleep efficiency during and after the 
intervention which improve preterm neonate's health and relaxation. Objective: was to investigate the 
effect of Yakson's therapeutic touch on vital signs, growth measurements and behavioral state of 
preterm neonates. Setting: This study was conducted at the Neonatal Intensive Care Unit (NICU) of 
Alexandria University Maternity Hospital (AUMH) -El Shatby and Smouha Children's University 
Hospital (SCUH). Subjects: A convenient sample of 60 preterm neonates who were randomly allocated 
to two equal groups (control and study). Tools: Three tools were used; preterm neonate's perinatal and 
admission data assessment sheet, preterm neonates' vital signs and growth measurements record and 
Anderson behavioral state scale (ABSS). Results: Very large effect size of Yakson therapeutic touch 
was found regarding preterm neonates' behavioral state (Cohen's D=3.58), mid arm circumference 
(Cohen's D=1.52) and the vital signs. Moreover, large effect size of Yakson's therapeutic touch was 
found on preterm neonates' length, chest and head circumference throughout the study phases (Cohen's 
D=0.88, Cohen's D=1.13, Cohen's D=1.02 respectively). Conclusion: Yakson's therapeutic touch has 
a significant effect on preterm neonates' vital signs stability, growth measurements increase and 
behavioral state score decrease.