Background: To provide nursing students with a more positive learning environment, the 
nursing faculty seeks to discover new effective teaching-learning strategies. One of these 
strategies is peer mentoring which allows students to assist and advise each other and 
helping them practicing nursing more efficiently. Study Aim: To determine the effect of 
peer-mentoring strategy on nursing students' infection control practice and its selfefficacy and stress. Settings: This study was conducted at the Technical Institute of 
Nursing in Sharq Elmadena Hospital in Alexandria, Egypt. Subjects: A convenient 
sample of 75 students, 15 mentors recruited from the student interns and 60 nursing 
students from the 4th academic year, who were randomly divided into two main mentees 
and control groups. Tools: Three tools were used. Tool one, "Nursing Students' Infection 
Control Performance Observational Checklist"; Tool two, “The Perceived Stress Scale 
(PSS)"; Tool three “Infection Control Practices Self-Efficacy Questionnaire. Results:
The study showed a significant improvement in infection control practice and selfefficacy in the study group more than in the control group. Furthermore, the study group 
exhibited significant lower stress levels than the control group. Conclusion: Peer 
mentoring is a great tactic strategy that can enhance nursing students' experiences in the 
clinical nursing field especially in the critical care units. It has been proven effectiveness
in decreasing stress and improving infection control practice and self-efficacy, which are 
all important factors in clinical practice. There was an overall positive feedback from the 
studied students regarding peer mentoring to be implemented into clinical education. 
The study further proves the significance of the strategy in nursing education.
Recommendations: Peer mentoring strategy should be considered as a significant 
teaching method in nursing education and its clinical practice. Training workshops 
should be conducted for nursing educators and students to enhance their abilities and 
competencies in using peer mentoring strategy.