Background: Cardiovascular disease is the most leading cause of increased morbidity and mortality. Coronary artery bypass graft surgery (CABG) has been known as an effective treatment for coronary artery disease that does not respond to pharmacological treatment. After CABG surgery, the patients experience moderate to severe postoperative sternal pain and hemodynamic instability. These may lead to subsequent complications that increase the length of hospital stay, cost, morbidity, and mortality rate. Tactile and auditory stimulation encompasses different techniques to control sternal pain and decrease physiological parameter alterations for post CABG patients. Objective: the current study is carried out to determine the effect of tactile and auditory stimulation on physiological parameters and the sternal pain among post CABG patients. Design: a quasi- experimental research design was used to fulfill the aim of the current study. Setting: The current study was carried out in the Open-Heart Critical Care Unit at Alexandria Main University Hospital which includes ten beds. Subjects: A convenient sample of 60 post CABG adult patients included in this study, they were conscious, able to communicate, and able to report their pain intensity verbally or nonverbally; 30 patients in each the intervention and control group. Tools: Two tools were used for data collection. Tool one: Socio-Demographic and Clinical Data Assessment, it was developed by the researcher, it consists of two parts. Tool two: Physiological Parameters and pain Assessment: It was used to assess the effect of the tactile and auditory stimulation on the physiological parameters and sternal pain, it consists of two parts. Part I was developed by the researcher, and part II was adopted from (Lazaridou et al., 2018). Results: The majority of the studied patients were males; their age were ranging from 50 to 60 years. Results of the study showed that there was a significant decrease in the sternal pain intensity and improvement in the mean scores of respiratory rates, spo2, heart rate post tactile and auditory stimulation. Conclusion: Tactile and auditory stimulations were effective as non-pharmacological measures in reducing the sternal pain and improving the physiological parameters in the patients post CABG.