Background: The COVID-19 pandemic has placed considerable strain on healthcare providers and showing high rates of stress and psychological health problems. Resilience is a critical skill for intern nurses and other healthcare professionals, especially during COVID-19 pandemic to help them to better cope during crisis and function more effectively in the workplace. Aim of study: Investigate the relationship between demographic determinants of intern nurses and resilience at work at Alexandria Main University Hospital. Research question: what is the relationship between demographic determinants of intern nurses and their resilience at work at Alexandria Main University Hospital? Descriptive-Correlational Research Design was used. Setting: Intensive Care Units and Critical care units and its specialties at Alexandria Main University Hospital. Sampling: Probability, systematic random sampling technique (n=56) of intern nurses were included in this study. Two tools were used in this study demographic data of intern nurses and Resilience at Work Scale (RAW-S). Results: Intern nurses reported moderate levels of resilience at work with a mean percent score of 49.06%. This study implies there were statistically significant differences between overall mean percent score of resilience at work and all demographic data and work -related characteristics except gender and marital status where (p value = 0.397, 0.632), respectively. Conclusions: the present study revealed that demographic and work-related characteristics affected on the resilience level positively. Recommendations: Intern nurses need to acquire the skills of resilience through provide training programs for intern nurses and develop strategies and guidelines to create resilient nurse.