Background: Hemodialysis (HD) associated problems contribute directly to further morbidity and mortality. Nurses have vital roles to play that involve wide range of activities in the prevention and management of hemodialysis related problems. These activities include continuous assessment of patients' condition as well as assuming the responsibility to carryout preventive measures and take proper actions when necessary. A significant portion of these problems fortunately may be preventable with applying the appropriate medical and nursing interventions. Objective: To identify common problems in functioning and disability among patients on maintenance hemodialysis. Setting and subjects: the study was conducted at the Hemodialysis Unit, Alexandria Fever Hospital in Egypt. (A convenience sample of 90 adult patients with end stage renal disease (ESRD) undergoing HD was selected), from the previously mentioned setting. Results: Significant correlations were observed between age and “activity limitations & participation restriction". A significant positive correlation was observed between age and “body function impairment" as (P < 0.018*). Conclusion: HD patients might experience prevalent problems during HD sessions, which need to be carefully assessed and managed. Recommendations: Expansion of medical services provided for hemodialysis patients in local health facilities to ensure continuity of care and follow up of patient undergoing HD health status, is highly recommended.