Thirst is the most common oral pathology manifestation in children undergoing hemodialysis. This symptom may lead to dehydration, depression and affect their quality of life. Non-traditional therapy such as acupressure has been recommended to be used for reducing thirst in children undergoing hemodialysis. Objective: Assess the effect of acupressure on thirst in children undergoing hemodialysis. Setting: The study was conducted at the Hemodialysis Unit at Alexandria University Children's Hospital. Subjects: A convenience sampling of 30 children undergoing hemodialysis comprised the study subjects, their ages ranged from 6-18 years. Tools: Two tools were used to collect the data of the study. Tool One: Socio Demographic and Medical Data of Children Undergoing Hemodialysis Interview Sheet, Tool Two: Dialysis Thirst Inventory Questionnaire. Results: Half of children reported very often thirsty before acupressure intervention. This percentage showed slightly decrease to 43.3% at the first week. Moreover, this percent decreased to 20% at the second week. Small proportion of those children (3.3%) reported that they had very often thirsty at the third and fourth weeks of the study period. Conclusion: Acupressure had great effect in reducing children's thirst intensity. Recommendation: Acupressure needs to be incorporated in pediatric hemodialysis unit policy and protocols to decrease thirst.