Hospital-acquired infections results due to lapsed compliance with Infection prevention and
control practices in health care set ups. Nurses provide direct care to the patients while performing
varied clinical procedures; therefore, they are pivotal in implementation of infection prevention and
control practices. Objective: Assess the nurses' compliance with infection prevention and control
practices in surgical units. Setting: The study was conducted at the Moi Teaching and Referral
Hospital Surgical wards Eldoret, Kenya. Subjects: Data was collected from 100 randomly selected
surgical nurses. Tools: Two tools were utilized; interviewer-administered questionnaire and
structured observational checklist. Results: Sixty nine percent of the nurses were compliant with
recommended hand hygiene practices; 99% of the nurses used gloves but fewer used other personal
protective equipment like goggles (25%) and gowns (37%). Seventy percent of were compliant with
safe injection practices. In overall, 85.6% of studied nurses reported to be compliant while 80% of
them were observed to be compliant. Conclusion: Most of the studied nurses complied with the
recommended infection prevention and control practices but compliance varied across different
domains of practice indications. Recommendations: The hospital should develop infection prevention
and control guidelines specific to surgical units.