Fertilization through the addition of nano-fertilizers, added in very small quantities as a foliar spray on the vine canopy, has become one of the most effective methods in order to reduce the amount of mineral fertilizers. Therefore, this experiment was conducted on a 7 year-old "Crimson seedless" grapevines for successive seasons 2021 and 2022 to determine the optimum rates of "Nano-NPK" fertilizer to replace the "NPK" conventional fertilizer. Three concentrations of "Nano-NPK" were used as foliar application in three concentrations, Nano - NPK (200, 30, 200 ppm), Nano-NPK (400, 60, 400 ppm) and Nano-NPK (800,120, 800 ppm) replacing 50% of conventional fertilizer NPK compared to the soil addition of the conventional fertilizer NPK at (25, 25, 100 kg/Feddan) as a control. Our results showed that Nano-NPK fertilizer at (800, 120, 800 ppm) induced a significant increase in yield parameters, along with the chemical and physical characteristics of the vegetative growth as compared with the lower concentrations but there are no significant differences between it and the control. Thus, application of Nano-fertilizers was very effective in accelerating the clusters growth stages along with replacing the mineral fertilizers