In the present study, we investigated the effect of foliar spray application of the amino acids compound “Pepton" at (1000 ppm), along with some vitamins (ascorbic acid at 500 ppm, vitamin E at 50 ppm, β–Sitosterol at 20 ppm), alone or combined with each other, on increasing the vegetative and reproductive growth and decreasing sun burned berries of Vitis vinifera cv. ‘Red Globe' grown under the Egyptian climate. The experiment which comprised eight treatments was conducted in the two successive seasons 2019–2020 with a preliminary season of 2018 in a private vineyard located at kilometer 55 Cairo–Alexandria desert road. Results showed that on days of maximum temperature of 35°C to 40°C, the vines treated with amino acids were about 8°C cooler, compared with the control in both seasons. This result was due to their positive effect on the increment of the leaves surface area which acts as a barrier, leading to effectively reduce some undesirable phenomena and improve the grape quality. In addition, results revealed that using the combined treatment of amino acids and ascorbic acid gave the highest significant increase in total soluble solids and improve yield quality, cluster weight, chlorophyll and anthocyanin content and decrease the percentage of sun burned berries in both seasons of investigation.