To investigate the effect of sucrose, yeast and landamine_Zn spraying and girdling on yield and berry quality of Flame Seedless grapes. Twenty four uniformly vine was selected, as eight treatments with three replications one vine each. The study was carried out during 2019 and 2020 seasons. The experiment set up in a randomized complete block design, where, the study included The obtained results could be summarized as follows; Yield/vine and cluster weight were significantly increased due to spray either sucrose, yeast or landamine_Zn as well as arm girdling compared to untreated ones (control). Spraying 4 g/L landamine_Zn was very effective in increasing yield and cluster weight than other treatments. Moreover, all studied treatments significantly improved the berry quality in terms of increasing berry weight, total soluble solids and anthocyanin in skin of berries and decreasing berry firmness and total acidity compared to untreated ones. The greatest results were obtained due to spraying landamine_Zn at 2 or 4 cm³/L where gave a high yield of good berry quality. No significant differences were obtained due to spray landamine_Zn at 2 or 4 cm³/L, as well as yeast, sucrose or girdling. It could be concluded that spraying 2 to 4 cm³/L landamine_Zn to get high yield with good cluster and berry quality of Flame Seedless grapes.