Background: Chronic kidney disease (CKD) is a world-wide public-health problem. According to the World Health Organization, diseases of the kidney and urinary tract contribute to global burden with approximately 850,000 deaths every year and more than 115 million disability-adjusted life years. Aim: The study aimed to assess the quality of life among chronic hemodialysis patients at Minia City. Study design: Descriptive research design had used to conduct in this study. Setting: This study was conducted at the outpatient clinic of hemodialysis unit at Minia university hospital and in the patients' home. Subject: A convenience sampling technique was utilized (100 chronic hemodialysis patients). Tools: Two tools were utilized in this study, the first tool was an interviewing structured questionnaire sheet was contained two parts: Part 1: Socio-demographic characteristics of chronic hemodialysis patients. Part II: Assess patient's medical history and the. Second tool was the assessment of the quality of life of chronic hemodialysis patientResults: the most of the chronic hemodialysis patient had poor quality of life (QOL) and the minority of them had fair QOL. Also there was a statistical significance between the total quality of life score and marital status with, educational level with, number of family members with, and income. Conclusion: The most of the chronic hemodialysis patient had poor QOL and there was a statistical significance between the total quality of life score and marital status with, educational level, number of family members, and income. Recommendations: Provide chronic hemodialysis patients with effective health education about hemodialysis therapy, diet schedule, medication, life style changes to improve their quality of life.