Background: Substance use disorders are a chronic and relapsing disease that difficulty to control despite harmful consequences‏. Self-efficacy, social support and treatment motivation shown to be important factors in the initiation and recognition enactment of behavioural changes. Aim of the Study: relationship between self-efficacy, social support, and treatment motivation among addict patients. Research design: A descriptive correlational research design will be utilized in the present study. Study subjects and setting: 153 addicts who are admitted at Minia psychiatric health and addiction treatment hospital including inpatients department and outpatients clinics. Tools: four tools were utilized in this study :Astructured interview and clinical data questionnaire, General self-efficacy scale, Social support appraisal scale and Treatment motivation scale. Results: the study findings showed that (96.7%)of studied sample were males, (51%) of them had secondary levels of education and (57.5%) was from urban areas. Moreover, total mean scored of self-efficacy, social support, and treatment motivation were higher among outpatients than inpatients. .Conclusions: There were a positive significant correlation between self-efficacy and social support. Moreover, there were a positive significant correlation between self-efficacy and treatment motivation & between social support and treatment motivation. Recommendations: Designing and implementing Psych-educational programs are essential for addict patients to improve self-efficacy and improve their motivation for treatment to prevent the problem of drug addiction.