Background:  Nurses face extra professional challenges due to the COVID-19 pandemic, which results in physical and mental health problems. Compassion fatigue and pandemic emotional impact are considered extra-additional stressful factors that affect nursing time and their abilities for time management. Aim: current study aimed to investigate the relationship between compassion fatigue, pandemic emotional impact, and time management among nurses at isolation hospitals during COVID-19. Research design: The present study utilized a descriptive correlational research design. Setting: The study was conducted at both Minia (fever and chest) hospitals. Sample: Two hundred registered nurses met inclusion and exclusion criteria.   Tools:  The personal interview sheet, the professional quality of life scale, the Pandemic emotional impact scale, and the time management questionnaire were used to compile the data. Results: Less than half of the studied sample was in the age group between 19 and < 29 years old, while the majority of them were females. Near two-thirds of the studied sample had a high level of total compassion fatigue. Also, more than half of them had a moderate level of pandemic emotional impact and time management. Conclusion: there is a statistically significant positive correlation between pandemic emotional impact and burnout subdomain of compassion fatigue. On the other hand, there is a statistically significant negative correlation between time planning with compassion fatigue (secondary traumatic stress. Recommendations: Educational workshops and periodical training programs should be implemented to reduce nurses' compassion fatigue and pandemic emotional impact and inspire nurses to work with effective time management techniques.