Background:  Uterine fibroids (UFs), also called uterine leiomyomas or myomas, are steroid hormone-responsive, benign tumors of the smooth muscle compartment (myometrium) of the uterus. Aim: This study aim was to evaluate the   effect of Educational Program on Knowledge Regarding Leiomyomas among Women in Reproductive Age.
Design: Quasi experimental research design (one group pre-test, post-test) was utilized to fulfill the aim of this study setting: This study was carried out at outpatient clinic and inpatient department of Obstetrics and Gynecology at Minia University Hospital for Obstetric & Pediatric (MUHOP) Hospital. Sampling: convenient sample includes 134 women Tools: The data collection tool consisted of two tools: the first tool: Interviewing questionnaire which include demographic characteristics of the women, the second tool: knowledge assessment tool. Results: regarding women knowledge , the present study revealed that the women knowledge improved after the educational program and there are a highly statistical significance differences between women knowledge level before and after implementing the educational program with P-value = 0.000**respectively.  Conclusion: the study concluded that the educational program was effective in improving women knowledge about leiomyoma .Recommendation: increase the number of educational programs about leiomyoma to improve women's   knowledge also provide posters, booklets and leaflets.