Background: The nursing job is one of the jobs in which there are many sources of pressure, which make workers are dissatisfied with their profession or their organizations, and their low level of quality of work life, which results in negative and cynical expressions that reflect on their job performance. Aim: to assess the effect of organizational cynicism on quality of work life and employee effectiveness among nursing staff. Research design: A descriptive research design was used. Subjects: Convenience sample, the study subjects were included all nurses who work at the three selected hospitals during the period of data collection with total number (no. =314). Setting: The study was conducted at Minia University Hospitals as (Obstetric and Pediatric Hospital, Liver Hospital and Kidney and Urology Hospital), Minia, Egypt. Affiliated to Minia University Hospitals. Scales of data collection: Included three scales as following: first scale "Organizational Cynicism Scale", second scale "Quality of Work Life Scale" and thirdscale "Employee Effectiveness Scale". Results: (50.6%) of studied nurses have moderate level of organizational cynicism, (52.5%) of them have moderate level of quality of work life and (55.4%) of them have moderate level of employee effectiveness. Conclusion: Organizational cynicism was negatively correlated to quality of work life and employee effectiveness, while quality of work life was positively correlated to employee effectiveness. Recommendations: Encourage nursing directors to adopt an open-door policy moreover, create a friendly work environment, and also further studies about relationship between organizational cynicism and Organizational ambidexterity.