Background: Effective clinical decision-making is important for the nurses and their employing organizations. Moreover developing nursing professional values is important because of promotion of care quality, increase of patient's understanding, increase of job satisfaction and retention of nursing staff. Aim of the study: to assess relation between clinical decision making and professional values among nurses at critical care units. Research design: A descriptive correlational research design was used. Subjects: Convenience sample, the study subjects were included all staff nurses working at Dairout central Hospital at critical care units during the period of data collection with total number (no.=122). Setting: The study was conducted on critical care units at Dairout central Hospital. Tools of data collection: included two; first tool" Clinical Decision Making Scale" and 2nd the second tool 'Nursing Professional Value Scale". Results: (77.9%) of studied nurses have high level of clinical decision-making; and (76.2%) of them have high level of professional values Conclusion: there were positive strong relation between nurses clinical decision making and their professional values. Recommendations: Training program for nurses about decision making skill, moreover training program for nurses about professional values, also further studies about relationship between professional values and clinical decision making among nurses working at general wards.